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Science 16 February 1979:
Vol. 203. no. 4381, pp. 656 - 658
DOI: 10.1126/science.569904
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Articles

Science, Vol 203, Issue 4381, 656-658
Copyright © 1979 by American Association for the Advancement of Science

articles

Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

CA Kasal, M Menaker, and Perez-Polo JR

N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm of enzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.


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Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture.
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Light and Norepinephrine Similarly Prevent Damping of the Melatonin Rhythm in Cultured Chick Pineal Cells: Regulation of Coupling between the Pacemaker and Overt Rhythms?.
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Differential Effects of Pinealectomy on Circadian Rhythms of Feeding and Perch Hopping in the European Starling.
E. Gwinner, R. Subbaraj, C. K. Bluhm, and M. Gerkema (1987)
J Biol Rhythms 2, 109-120
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Regulation of circadian rhythmicity.
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Circadian rhythm of serotonin N-acetyltransferase activity in organ culture of chicken pineal gland.
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Circadian Activation of Bullfrog Retinal Mitogen-activated Protein Kinase Associates with Oscillator Function.
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