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Science 9 February 1979:
Vol. 203. no. 4380, pp. 550 - 553
DOI: 10.1126/science.104388
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Articles

Science, Vol 203, Issue 4380, 550-553
Copyright © 1979 by American Association for the Advancement of Science

articles

Eye malformations in rats: induction by prenatal exposure to nickel carbonyl

FW Sunderman Jr, PR Allpass, JM Mitchell, RC Baselt, and DM Albert

Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anophthalmia in Litters of Female Rats Treated with the Food-Derived Carcinogen, 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine.
Y. Ikeda, S. Takahashi, J. Kimura, Y.-M. Cho, K. Imaida, S. Shirai, and T. Shirai (1999)
Toxicol Pathol 27, 628-631
   Abstract »    PDF »
Nickel Carbonyl: Decomposition in Air and Related Kinetic Studies.
D. H. STEDMAN, D. A. HIKADE, R. PEARSON JR., and E. D. YALVAC (1980)
Science 208, 1029-1031
   Abstract »    PDF »
Nickel carbonyl: prenatal exposure.
J. Warner (1979)
Science 203, 1194-1195
   PDF »


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