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Science 9 February 1979:
Vol. 203. no. 4380, pp. 548 - 550
DOI: 10.1126/science.216077
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Articles

Science, Vol 203, Issue 4380, 548-550
Copyright © 1979 by American Association for the Advancement of Science

articles

Rotaviral immunity in gnotobiotic calves: heterologous resistance to human virus induced by bovine virus

RG Wyatt, CA Mebus, RH Yolken, AR Kalica, HD James Jr, AZ Kapikian, and RM Chanock

The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains.
J. Matthijnssens, M. Ciarlet, E. Heiman, I. Arijs, T. Delbeke, S. M. McDonald, E. A. Palombo, M. Iturriza-Gomara, P. Maes, J. T. Patton, et al. (2008)
J. Virol. 82, 3204-3219
   Abstract »    Full Text »    PDF »
Antibody-Secreting Cell Responses to Rotavirus Proteins in Gnotobiotic Pigs Inoculated with Attenuated or Virulent Human Rotavirus.
K. O. Chang, O. H. Vandal, L. Yuan, D. C. Hodgins, and L. J. Saif (2001)
J. Clin. Microbiol. 39, 2807-2813
   Abstract »    Full Text »    PDF »
Immune Response of Infants and Children to Low-Passage Bovine Rotavirus (Strain WC3).
H F. Clark, T. Furukawa, L. M. Bell, P. A. Offit, P. A. Perrella, and S. A. Plotkin (1986)
Arch Pediatr Adolesc Med 140, 350-356
   Abstract »    PDF »


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