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Science 9 February 1979:
Vol. 203. no. 4380, pp. 516 - 521
DOI: 10.1126/science.104386
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Articles

Science, Vol 203, Issue 4380, 516-521
Copyright © 1979 by American Association for the Advancement of Science

articles

The major histocompatibility complex of the mouse

J Klein

Like physicists striving to develop a unified field theory, immunologists are attempting to bring order to the microcosmos of defense reactions. Indications are that one of the most important constants in this microcosmos is the major histocompatibility complex (MHC) of the species. A test of any interpretation of the MHC's role in immunity is how well it explains this system's polymorphism. One of the most crucial questions an MHC hypothesis must answer is: Why are there so many alleles at this complex?


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. S. Block, Y. V. Mendez-Fernandez, V. P. Van Keulen, M. J. Hansen, K. S. Allen, A. L. Taboas, M. Rodriguez, and L. R. Pease (2005)
J. Immunol. 174, 2756-2762
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MHC-Restricted T-cell Recognition: The Basis of Immune Surveillance.
R. M. Zinkernagel (1995)
JAMA 274, 1069-1071
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Polymorphism and Regulation of HLA Class II Genes of the Major Histocompatibility Complex.
B. Mach, J. Gorski, P. Rollini, C. Berte, I. Amaldi, J. Berdoz, and C. Ucla (1986)
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Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia.
P. Pelicci, L Lanfrancone, M. Brathwaite, Wolman SR, and R Dalla-Favera (1984)
Science 224, 1117-1121
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Genes of the major histocompatibility complex in mouse and man.
M Steinmetz and L Hood (1983)
Science 222, 727-733
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Activation and Regulation of Human Immune Responses: Implications in Normal and Disease States.
A. S. FAUCI, H. C. LANE, and D. J. VOLKMAN (1983)
Ann Intern Med 99, 61-75
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Genes of the Major Histocompatibility Complex.
L. Hood, M. Steinmetz, R. Goodenow, K. Eakle, D. Fisher, J. Kobori, B. Malissen, M. Malissen, M. McMillan, J. McNicholas, et al. (1983)
Cold Spring Harb Symp Quant Biol 47, 1051-1065
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Structure and Expression of the Human Globin Genes and Murine Histoeompatability Antigen Genes.
R.A. Flavell, F. Grosveld, M. Busslinger, E. de Boer, D. Kioussis, A.L. Mellor, L. Golden, E. Weiss, J. Hurst, H. Bud, et al. (1983)
Cold Spring Harb Symp Quant Biol 47, 1067-1078
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Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer.
R. Goodenow, M McMillan, A Orn, M Nicolson, N Davidson, J. Frelinger, and L Hood (1982)
Science 215, 677-679
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DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.
K. Moore, B. Sher, Y. Sun, K. Eakle, and L Hood (1982)
Science 215, 679-682
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The major histocompatibility complex in man.
J Dausset (1981)
Science 213, 1469-1474
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Organization of the immune response genes.
J. Uhr, J. Capra, E. Vitetta, and R. Cook (1979)
Science 206, 292-297
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Science. ISSN 0036-8075 (print), 1095-9203 (online)