Related Content
Search Google Scholar for:
|
|
Science 26 January 1979:
Vol. 203. no. 4378, pp. 374 - 376
DOI: 10.1126/science.760197
|
|
Articles
Science, Vol 203, Issue 4378, 374-376
Copyright © 1979 by American Association for the Advancement of Science
Fever and reduced iron: their interaction as a host defense response to bacterial infection
MJ Kluger
and
BA Rothenburg
When rabbits are infected with Pasteurella multocida, the concentration of iron in their plasma decreases and their rectal temperature rises. To determine whether the rise in body temperature (fever) and the fall in plasma iron may be a coordinated host defense response, Pasteurella multocida were grown in vitro at various temperatures and iron concentrations. At afebrile temperatures the bacteria grew equally well at low or high concentrations of iron. However, when the temperature of the bath was raised to a febrile temperature the growth of the bacteria was inhibited by the low, but not the high, iron concentrations. These data support the hypothesis that one of the mechanisms behind the adaptive (or beneficial) role of fever is the reduced ability of pathogenic bacteria to grow well at elevated temperatures in an iron-poor medium.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Immune and behavioral consequences of microglial reactivity in the aged brain.
- A. M. Wynne, C. J. Henry, and J. P. Godbout (2009)
Integr. Comp. Biol.
49, 254-266
| Abstract »
| Full Text »
| PDF »
- Bidirectional communication: Growth and immunity in domestic livestock.
- J. A. Carroll (2008)
J Anim Sci
86, E126-E137
| Abstract »
| Full Text »
| PDF »
- Prostacyclin signaling regulates circulating ghrelin during acute inflammation.
- L. D Madison, J. M Scarlett, P. Levasseur, X. Zhu, K. Newcomb, A. Batra, D. Bowe, and D. L Marks (2008)
J. Endocrinol.
196, 263-273
| Abstract »
| Full Text »
| PDF »
- Attenuated fever in rats during late pregnancy is linked to suppressed interleukin-6 production after localized inflammation with turpentine.
- A. Aguilar-Valles, S. Poole, Y. Mistry, S. Williams, and G. N. Luheshi (2007)
J. Physiol.
583, 391-403
| Abstract »
| Full Text »
| PDF »
- Peripubertal Immune Challenges Attenuate Reproductive Development in Male Siberian Hamsters (Phodopus sungorus).
- B. J. Prendergast, A. K. Hotchkiss, S. D. Bilbo, and R. J. Nelson (2004)
Biol Reprod
70, 813-820
| Abstract »
| Full Text »
| PDF »
- Melatonin Regulates Energy Balance and Attenuates Fever in Siberian Hamsters.
- S. D. Bilbo and R. J. Nelson (2002)
Endocrinology
143, 2527-2533
| Abstract »
| Full Text »
| PDF »
- A Persistent Biochemical Marker for Partially Treated Meningitis/Ventriculitis.
- R. Katnik (1995)
J Child Neurol
10, 93-99
| Abstract »
| PDF »
- Antipyresis and Fever.
- B. Styrt and B. Sugarman (1990)
Arch Intern Med
150, 1589-1597
| Abstract »
| PDF »
- Effect of Sepsis and Surgery on Trace Minerals.
- L.K.R. Shanbhogue and N. Paterson (1990)
JPEN J Parenter Enteral Nutr
14, 287-289
| Abstract »
| PDF »
- Manifestations of Sepsis.
- R. L. Harris, D. M. Musher, K. Bloom, J. Gathe, L. Rice, B. Sugarman, T. W. Williams Jr, and E. J. Young (1987)
Arch Intern Med
147, 1895-1906
| Abstract »
| PDF »
- Endogenous pyrogen activity in human plasma after exercise.
- J. Cannon and M. Kluger (1983)
Science
220, 617-619
| Abstract »
| PDF »
- Infections and Iron: Too Much of a Good Thing?.
- J. A. STOCKMAN III (1981)
Arch Pediatr Adolesc Med
135, 18-20
| Abstract »
| PDF »
- Global differential gene expression in response to growth temperature alteration in group A Streptococcus.
- L. M. Smoot, J. C. Smoot, M. R. Graham, G. A. Somerville, D. E. Sturdevant, C. A. L. Migliaccio, G. L. Sylva, and J. M. Musser (2001)
PNAS
98, 10416-10421
| Abstract »
| Full Text »
| PDF »
|
|
