Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 January 1979:
Vol. 203. no. 4378, pp. 365 - 367
DOI: 10.1126/science.216075
Prev | Table of Contents | Next

Articles

Science, Vol 203, Issue 4378, 365-367
Copyright © 1979 by American Association for the Advancement of Science

articles

Lithium: a modulator of cyclic AMP-dependent events in lymphocytes?

EW Gelfand, HM Dosch, B Hastings, and A Shore

Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lithium and hematology: established and proposed uses.
D. Focosi, A. Azzara, R. E. Kast, G. Carulli, and M. Petrini (2009)
J. Leukoc. Biol. 85, 20-28
   Abstract »    Full Text »    PDF »
Effect of Lithium on Incorporation of Bromodeoxyuridine and Tritiated Thymidine Into Human Parathyroid Cells.
A. Saxe and G. Gibson (1993)
Arch Surg 128, 865-869
   Abstract »    PDF »
The Mechanisms of Action of Lithium: II. Effects on Adenylate Cyclase Activity and {beta}-Adrenergic Receptor Binding in Normal Subjects.
E. D. Risby, J. K. Hsiao, H. K. Manji, J. Bitran, F. Moses, D. F. Zhou, and W. Z. Potter (1991)
Arch Gen Psychiatry 48, 513-524
   Abstract »    PDF »
Lithium Carbonate Therapy in Severe Felty's Syndrome: Benefits, Toxicity, and Granulocyte Function.
M. J. Mant, J. J. Akabutu, and F. A. Herbert (1986)
Arch Intern Med 146, 277-280
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)