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Science 26 January 1979:
Vol. 203. no. 4378, pp. 361 - 363
DOI: 10.1126/science.760195
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Articles

Science, Vol 203, Issue 4378, 361-363
Copyright © 1979 by American Association for the Advancement of Science

articles

Mammary cancer: selective action of the estrogen receptor complex

M Ip, RJ Milholland, F Rosen, and U Kim

Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.


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Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.
M. Sun, Z. Estrov, Y. Ji, K. R. Coombes, D. H. Harris, and R. Kurzrock (2008)
Mol. Cancer Ther. 7, 464-473
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Science. ISSN 0036-8075 (print), 1095-9203 (online)