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Science 19 January 1979:
Vol. 203. no. 4377, pp. 265 - 268
DOI: 10.1126/science.569901
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Articles

Science, Vol 203, Issue 4377, 265-268
Copyright © 1979 by American Association for the Advancement of Science

articles

In vitro model for stretch-induced hypertrophy of skeletal muscle

H Vandenburgh and S Kaufman

Mechanical stretch of embryonic chicken skeletal myotubes developed in vitro leads to many of the biochemical changes seen in skeletal muscle hypertrophy. These include increased amino acid accumulation, increased incorporation of amino acids into general cellular proteins and myosin heavy chains, and increased accumulation of total protein and myosin heavy chains. This model system should aid in understanding how the growth rate of skeletal muscle is regulated by its activity.


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