Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 January 1979:
Vol. 203. no. 4376, pp. 179 - 182
DOI: 10.1126/science.758686
Prev | Table of Contents | Next

Articles

Science, Vol 203, Issue 4376, 179-182
Copyright © 1979 by American Association for the Advancement of Science

articles

Tumor surveillance: how tumors may resist macrophage-mediated host defense

J Rhodes, M Bishop, and J Benfield

Both normal human serum and supernatant from explanted malignant tumors contained a heat-stable low-molecular-weight factor that inhibited monocyte activation in vitro. In contrast, serum from individuals with solid tumors enhanced monocyte activation. It is suggested that the systemic activation of monocytes that occurs in malignant disease may be an appropriate host response but that successful tumors may continue to grow because they subvert the normal physiological signal for inhibition of macrophage activation.




To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)