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Science 12 January 1979:
Vol. 203. no. 4376, pp. 179 - 182
DOI: 10.1126/science.758686
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Articles

Science, Vol 203, Issue 4376, 179-182
Copyright © 1979 by American Association for the Advancement of Science

articles

Tumor surveillance: how tumors may resist macrophage-mediated host defense

J Rhodes, M Bishop, and J Benfield

Both normal human serum and supernatant from explanted malignant tumors contained a heat-stable low-molecular-weight factor that inhibited monocyte activation in vitro. In contrast, serum from individuals with solid tumors enhanced monocyte activation. It is suggested that the systemic activation of monocytes that occurs in malignant disease may be an appropriate host response but that successful tumors may continue to grow because they subvert the normal physiological signal for inhibition of macrophage activation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)