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Science 12 January 1979:
Vol. 203. no. 4376, pp. 176 - 179
DOI: 10.1126/science.569363
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Articles

Science, Vol 203, Issue 4376, 176-179
Copyright © 1979 by American Association for the Advancement of Science

articles

Chemotactic responses of tumor cells to products of resorbing bone

W Orr, J Varani, MK Gondex, PA Ward, and GR Mundy

To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.


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