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Science 12 January 1979:
Vol. 203. no. 4376, pp. 174 - 176
DOI: 10.1126/science.569362
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Articles

Science, Vol 203, Issue 4376, 174-176
Copyright © 1979 by American Association for the Advancement of Science

articles

Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers

GG Johnson, LR Eisenberg, and BR Migeon

Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.


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Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells.
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Expression of a retrovirus encoding human HPRT in mice.
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