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Science 5 January 1979:
Vol. 203. no. 4375, pp. 68 - 69
DOI: 10.1126/science.758680
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Articles

Science, Vol 203, Issue 4375, 68-69
Copyright © 1979 by American Association for the Advancement of Science

articles

Cholecystokinin in the brains of obese and nonobese mice

E Straus and RS Yalow

Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
P. Faris, B. Komisaruk, L. Watkins, and D. Mayer (1983)
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Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep.
M. Della-Fera, C. Baile, B. Schneider, and J. Grinker (1981)
Science 212, 687-689
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Cholecystokinin receptors in the brain: characterization and distribution.
A Saito, H Sankaran, I. Goldfine, and J. Williams (1980)
Science 208, 1155-1156
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Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding.
M. Della-Fera and C. Baile (1979)
Science 206, 471-473
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