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Science 5 January 1979:
Vol. 203. no. 4375, pp. 55 - 57
DOI: 10.1126/science.83000
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Articles

Science, Vol 203, Issue 4375, 55-57
Copyright © 1979 by American Association for the Advancement of Science

articles

N-acetyl gramicidin: single-channel properties and implications for channel structure

G Szabo and DW Urry

Substitution of a methyl group for the N-terminal hydrogen of gramicidin greatly increased the rate of dissociation of conductive channels in lipid bilayer membranes. The finding of short lifetimes for conductive channels, comparable to those seen for the neuromuscular junction, lends support to the head-to-head dimer structure for the conductive channel.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)