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Science 22 December 1978:
Vol. 202. no. 4374, pp. 1303 - 1306
DOI: 10.1126/science.725608
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Articles

Science, Vol 202, Issue 4374, 1303-1306
Copyright © 1978 by American Association for the Advancement of Science

articles

Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin

C de Montigny and GK Aghajanian

Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.


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