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Science 22 December 1978:
Vol. 202. no. 4374, pp. 1300 - 1303
DOI: 10.1126/science.725607
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Articles

Science, Vol 202, Issue 4374, 1300-1303
Copyright © 1978 by American Association for the Advancement of Science

articles

Endoplasmic reticulum sequesters calcium in the squid giant axon

MP Henkart, TS Reese, and FJ Brinley Jr

Axons were loaded with calcium, rapidly frozen, and freeze-substituted. The endoplasmic reticulum, in addition to mitochondria, contained calcium deposits, as indicated by electron probe x-ray microanalysis. Oxalate injected into living axons helped to preserve calcium-containing deposits during preparation for microscopy. It is concluded that the endoplasmic reticulum is a calcium-sequestering compartment in the squid giant axon.


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Microheterogeneity of calcium signalling in dendrites.
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Activity-Dependent Calcium Sequestration in Dendrites of Hippocampal Neurons in Brain Slices.
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