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Science 15 December 1978:
Vol. 202. no. 4373, pp. 1198 - 1120
DOI: 10.1126/science.214852
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Articles

Science, Vol 202, Issue 4373, 1198-1120
Copyright © 1978 by American Association for the Advancement of Science

articles

The pineal gland: a biological clock in vitro

SA Binkley, JB Riebman, and KB Reilly

Circadian rhythmicity was studied by following the course of N-acetyl-transferase activity in the pineal glands of chickens in vitro. The results indicate (i) a daily change during day 1 of organ culture in constant dark that was dependent on the time the chickens were killed, (ii) equivocal persistence of the daily change in constant dark during 6 to 7 days of organ culture, (iii) an effect of light, (iv) inhibition by adrenergic agents and cycloheximide, and (v) stimulation by dibutyryl adenosine 3',5'-monophosphate and related compounds.


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