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Science 8 December 1978:
Vol. 202. no. 4372, pp. 1094 - 1096
DOI: 10.1126/science.202.4372.1094
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Articles

Halohydrocarbon Synthesis by Bromoperoxidase

RICHARD THEILER 1, J. CARTER COOK 1, LOWELL P. HAGER 1, and JEROME F. SIUDA 2

1 Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana 61802
2 Department of Medicinal Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

An enzyme extracted from marine red algae, Bonnemaisonia hamifera, is capable of incorporating bromine into a number of organic substrates in the pH range 5 to 8. At pH 7.3, incubation of partially purified preparations of bromoperoxidase with hydrogen peroxide, bromide ion, and 3-oxooctanoic acid leads to the formation of three volatile brominated hydrocarbons: dibromomethane, bromoform, and 1-pentyl bromide. The presence of significant quantities of halometabolites including volatile halohydrocarbons in marine organisms, ocean waters, and the upper atmosphere may result from peroxidase-catalyzed halogenation reactions.

Submitted on April 14, 1978
Revised on August 8, 1978


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Volatile Halogenated Organic Compounds Released to Seawater from Temperate Marine Macroalgae.
P. M. Gschwend, P. M. GSCHWEND, J. K. MACFARLANE, and K. A. NEWMAN (1985)
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Natural Products Chemistry in the Marine Environment.
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