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Science 8 December 1978:
Vol. 202. no. 4372, pp. 1089 - 1091
DOI: 10.1126/science.213833
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Articles

Science, Vol 202, Issue 4372, 1089-1091
Copyright © 1978 by American Association for the Advancement of Science

articles

Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation

TH Svensson and T Usdin

The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.


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Invited commentary: complexities in evaluating neurobiological models for stress resistance.
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Behavioral and Physiologic Effects of Short-term and Long-term Administration of Clonidine in Panic Disorder.
T. W. Uhde, M. B. Stein, B. J. Vittone, L. J. Siever, J.-P. Boulenger, E. Klein, and T. A. Mellman (1989)
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Clonidine challenge testing of alpha-2-adrenoceptor function in man: the effects of mental illness and psychotropic medication.
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Abnormal Regulation of Noradrenergic Function in Panic Disorders: Effects of Clonidine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder.
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Arch Gen Psychiatry 43, 1059-1065
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Noradrenergic Function and the Mechanism of Action of Antianxiety Treatment: I. The Effect of Long-term Alprazolam Treatment.
D. S. Charney and G. R. Heninger (1985)
Arch Gen Psychiatry 42, 458-467
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Noradrenergic Function and the Mechanism of Action of Antianxiety Treatment: II. The Effect of Long-term Imipramine Treatment.
D. S. Charney and G. R. Heninger (1985)
Arch Gen Psychiatry 42, 473-481
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Noradrenergic Function in Panic Anxiety: Effects of Yohimbine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder.
D. S. Charney, G. R. Heninger, and A. Breier (1984)
Arch Gen Psychiatry 41, 751-763
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Strain differences in rat brain epinephrine synthesis: regulation of alpha-adrenergic receptor number by epinephrine.
B. Perry, J. Stolk, G Vantini, R. Guchhait, and D. U'Prichard (1983)
Science 221, 1297-1299
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Electroconvulsive Treatment and Lithium Carbonate: Their Effects on Norepinephrine Metabolism in Patients With Primary, Major Depressions.
M. Linnoila, F. Karoum, N. Rosenthal, and W. Z. Potter (1983)
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Alteration of Norepinephrine Metabolism With Desipramine and Zimelidine in Depressed Patients.
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Neurotransmitters in Anxiety.
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Arch Gen Psychiatry 39, 735-742
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Impaired Presynaptic Regulation of Norepinephrine in Schizophrenia: Effects of Clonidine in Schizophrenic Patients and Normal Controls.
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Arch Gen Psychiatry 39, 285-289
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Adrenergic Receptor Sensitivity in Depression: Effects of Clonidine in Depressed Patients and Healthy Subjects.
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Platelet {alpha}2-Adrenergic Receptors in Major Depressive Disorder: Binding of Tritiated Clonidine Before and After Tricyclic Antidepressant Drug Treatment.
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Arch Gen Psychiatry 38, 1327-1333
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Presynaptic Adrenergic Receptor Sensitivity in Depression: The Effect of Long-term Desipramine Treatment.
D. S. Charney, G. R. Heninger, D. E. Sternberg, D. E. Redmond, J. F. Leckman, J. W. Maas, and R. H. Roth (1981)
Arch Gen Psychiatry 38, 1334-1340
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Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression.
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Phase advance of the circadian sleep-wake cycle as an antidepressant.
T. Wehr, A Wirz-Justice, F. Goodwin, W Duncan, and J. Gillin (1979)
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