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Science 1 December 1978:
Vol. 202. no. 4371, pp. 988 - 991
DOI: 10.1126/science.715455
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Articles
Science, Vol 202, Issue 4371, 988-991
Copyright © 1978 by American Association for the Advancement of Science
beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa)
DL Margules,
B Moisset,
MJ Lewis,
H Shibuya,
and
CB Pert
Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.
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