Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 November 1978:
Vol. 202. no. 4370, pp. 905 - 907
DOI: 10.1126/science.715450
Prev | Table of Contents | Next

Articles

Science, Vol 202, Issue 4370, 905-907
Copyright © 1978 by American Association for the Advancement of Science

articles

Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity

WJ McEntee and RG Mair

The concentration of the primary brain metabolite of norepinephrine is diminished in the lumbar spinal fluid of patients with Korsakoff's syndrome. The extent of its reduction is significantly correlated with measures of memory impairment for individual patients. These data suggest that the memory disorder of Korsakoff's syndrome may result from damage to ascending noradrenergic pathways by the diencephalic and brainstem lesions associated with this disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Presbyophrenia: A Possible Subtype of Dementia.
I. M. Zervas, J. M. Fliesser, M. Woznicki, and G. L. Fricchione (1993)
J Geriatr Psychiatry Neurol 6, 25-28
   Abstract »    PDF »
Cerebrospinal Fluid Monoamine Metabolite Levels in Male Arsonists.
M. Virkkunen, A. Nuutila, F. K. Goodwin, and M. Linnoila (1987)
Arch Gen Psychiatry 44, 241-247
   Abstract »    PDF »
A Psychobiologic Analysis of Cognitive Failures: Structure and Mechanisms.
P. N. Tariot and H. Weingartner (1986)
Arch Gen Psychiatry 43, 1183-1188
   Abstract »    PDF »
Response to ethanol reduced by past thiamine deficiency.
P. Martin, E Majchrowicz, E Tamborska, C Marietta, A. Mukherjee, and M. Eckardt (1985)
Science 227, 1365-1368
   Abstract »    PDF »
Reaction Time and Vigilance in Parkinson's Disease: Possible Role of Altered Norepinephrine Metabolism.
Y. Stern, R. Mayeux, and L. Cote (1984)
Arch Neurol 41, 1086-1089
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)