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Science 17 November 1978:
Vol. 202. no. 4369, pp. 772 - 775
DOI: 10.1126/science.715442
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Articles

Science, Vol 202, Issue 4369, 772-775
Copyright © 1978 by American Association for the Advancement of Science

articles

Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current

WA Wilson and H Wachtel

By using voltage clamping and microiontophoretic techniques, it has been found that the prolonged cholinergic and dopaminergic inhibition seen in Aplysia burst firing neurons occludes the inward current on which slow oscillations depend. It also mimics the temperature and ionic sensitivity of that inward current. This prolonged inhibition, which cannot be inverted and is insensitive to extracellular potassium changes, thus appears to result from a synaptically produced inactivation of the regenerative slow inward current underlying bursting.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Molecular biology of learning: modulation of transmitter release.
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