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Science 3 November 1978:
Vol. 202. no. 4367, pp. 537 - 539
DOI: 10.1126/science.705344
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Articles

Science, Vol 202, Issue 4367, 537-539
Copyright © 1978 by American Association for the Advancement of Science

articles

Aphagia and adipsia after preferential destruction of nerve cell bodies in hypothalamus

SP Grossman, D Dacey, AE Halaris, T Collier, and A Routtenberg

Microinjections of the excitatory neurotoxin kainic acid into the lateral hypothalamus of rats produced a period aphagia and adipsia. Kainate-treated rats displayed transient motor effects during the first hours after the injection but did not show the persisting sensory-motor and arousal disturbances typically observed in animals with electrolytic lesions in this part of the hypothalamus. Histological examination revealed a significant reduction in the number of nerve cell bodies in the lateral hypothalamus. Silver-stained material indicated no evidence of damage to fiber systems passing through the affected region. Assays of dopamine in hypothalamus, striatum, and telencephalon did not indicate significant differences between experimental and control animals. These results are in agreement with recent reports of the anatomical and biochemical effects of intracerebral kainic acid injections and suggest that the observed effect on feeding behavior is related to the destruction of neurons in the lateral hypothalamus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Y. K. Cho, C.-S. Li, and D. V. Smith (2003)
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The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat.
C. L. Chaffer and M. J. Morris (2002)
Endocrinology 143, 191-197
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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity.
L. de Lecea, T. S. Kilduff, C. Peyron, X.-B. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. F. Battenberg, V. T. Gautvik, F. S. Bartlett II, et al. (1998)
PNAS 95, 322-327
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The Hypothalamic Ventromedial Nuclei Couple Activity in the Hypothalamo-Pituitary-Adrenal Axis to the Morning Fed or Fasted State.
S. Choi, C. Horsley, S. Aguila, and M. F. Dallman (1996)
J. Neurosci. 16, 8170-8180
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Food-Anticipatory Circadian Rhythms in Rats with Paraventricular and Lateral Hypothalamic Ablations.
R. E. Mistlberger and B. Rusak (1988)
J Biol Rhythms 3, 277-291
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Science. ISSN 0036-8075 (print), 1095-9203 (online)