Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 October 1978:
Vol. 202. no. 4366, pp. 440 - 442
DOI: 10.1126/science.568309
Prev | Table of Contents | Next

Articles

Science, Vol 202, Issue 4366, 440-442
Copyright © 1978 by American Association for the Advancement of Science

articles

Selective inhibition of tubulin synthesis by amiprophos methyl during flagellar regeneration in Chlamydomonas reinhardi

PS Collis and DP Weeks

Amiprophos methyl (APM) is a strong, readily reversible and highly selective inhibitor of tubulin synthesis in Chlamydomonas reinhardi. The extensive induction of tubulin synthesis that accompanies flagellar regeneration in this organism is prevented by 3 to 10 micrometerAPM. When applied after induction has begun, APM causes a rapid cessation of tubulin synthesis. Translation studies in vitro indicate that the lack of tubulin production in APM-treated cells is not due to a direct inhibition of tubulin messenger RNA translation but rather to a selective depletion of tubulin messenger RNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Meiotic telomere clustering is inhibited by colchicine but does not require cytoplasmic microtubules.
C. R. Cowan and W. Z. Cande (2002)
J. Cell Sci. 115, 3747-3756
   Abstract »    Full Text »    PDF »
Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl.
L. C. MOREJOHN and D. E. FOSKET (1984)
Science 224, 874-876
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)