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Science 27 October 1978:
Vol. 202. no. 4366, pp. 436 - 438
DOI: 10.1126/science.705336
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Articles

Science, Vol 202, Issue 4366, 436-438
Copyright © 1978 by American Association for the Advancement of Science

articles

Prenatal exposure to prednisone in humans and animals retards intrauterine growth

JM Reinisch, NG Simon, WG Karow, and R Gandelman

Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.


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The role of 11{beta}-hydroxysteroid dehydrogenase in the pathogenesis of hypertension.
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Differential Regulation of 11 {beta}-Hydroxysteroid Dehydrogenase Type 1 and 2 by Nitric Oxide in Cultured Human Placental Trophoblast and Chorionic Cell Preparation.
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   Abstract »    Full Text »    PDF »
How Safe Is Long-term Prenatal Glucocorticoid Treatment?.
J. R. Seckl and W. L. Miller (1997)
JAMA 277, 1077-1079
   Abstract »    PDF »
11{beta}-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess.
P. C. White, T. Mune, and A. K. Agarwal (1997)
Endocr. Rev. 18, 135-156
   Abstract »    Full Text »
Differential Expression of 11{beta}-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta and Fetal Membranes.
K. Sun, K. Yang, and J. R. G. Challis (1997)
J. Clin. Endocrinol. Metab. 82, 300-305
   Abstract »    Full Text »    PDF »
Inherited Forms of Mineralocorticoid Hypertension.
P. C. White (1996)
Hypertension 28, 927-936
   Abstract »    Full Text »
Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress.
A. Barbazanges, P. V. Piazza, M. Le Moal, and S. Maccari (1996)
J. Neurosci. 16, 3943-3949
   Abstract »    Full Text »    PDF »
Inhibition of 11ß-Hydroxysteroid Dehydrogenase in Pregnant Rats and the Programming of Blood Pressure in the Offspring.
R. S. Lindsay, R. M. Lindsay, C. R.W. Edwards, and J. R. Seckl (1996)
Hypertension 27, 1200-1204
   Abstract »    Full Text »
Prednisone Therapy and Birth Weight.
J. M. REINISCH, N. G. SIMON, W. G. KAROW, and R. GANDELMAN (1979)
Science 206, 97
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