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Science 20 October 1978:
Vol. 202. no. 4365, pp. 320 - 321
DOI: 10.1126/science.694537
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Articles

Science, Vol 202, Issue 4365, 320-321
Copyright © 1978 by American Association for the Advancement of Science

articles

Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series

RM Schultz, NA Pavlidis, WA Stylos, and MA Chirigos

Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities.


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Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes.
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Review : Polynucleotides as Interferon Inducers and Immune Modulators.
H. B. Levy (1986)
Journal of Bioactive and Compatible Polymers 1, 348-385
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Prostaglandins and Other Metabolites of Arachidonic Acid: An Overview for the Otolaryngologist.
M. D. Poole and H. C. Pillsbury III (1985)
Arch Otolaryngol Head Neck Surg 111, 317-321
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Interferons: Rationale for Clinical Trials in Neoplastic Disease.
E. C. BORDEN (1979)
Ann Intern Med 91, 472-479
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