Science, Vol 202, Issue 4365, 318-319
Copyright © 1978 by American Association for the Advancement of Science
Alkaline phosphatase in Epstein-Barr viral nuclear antigen--positive cell lines
A Karpas,
FG Hayhoe,
J Greenberger,
and
H Neumann
The production and nature of alkaline phosphatase were studied in Epstein-Barr viral nuclear antigen-positive, surface membrane immunoglobulin negative-cell lines established from two patients, one with acute myeloid leukemia and one with acute lymphoblastic leukemia. The acute myeloid leukemia-derived cells contained myeloid alkaline phosphatase, while the acute lymphoblastic leukemia-derived cells contained lymphoid alkaline phosphatase. The presence of the myeloid-specific enzyme in a surface membrane immunoglobin--negative cell line suggests that the line is composed of myeloid precursor cells and that such cells may be susceptible to infection with Epstein-Barr virus.
