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Science 20 October 1978:
Vol. 202. no. 4365, pp. 280 - 286
DOI: 10.1126/science.694532
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Articles

Science, Vol 202, Issue 4365, 280-286
Copyright © 1978 by American Association for the Advancement of Science

articles

Nucleosome arcs and helices

J Dubochet and M Noll

Crystals and other regular arrangements of nucleosome cores have been obtained and analyzed in the electron microscope. Two types of regular structures have been studied in detail, the nucleosome arcs and cylinders. The latter are composed of concentric cylindrical layers of intertwined right-handed helices of nucleosome cores. These studies lead to the following conclusions and concepts. The overall structure of the nucleosome core is a short, wedge-shaped cylinder measuring about 110 by 110 by 60 angstroms. Nucleosome cores interact primarily between top and bottom planes. Nucleosome cores exhibit large conformational variability. A pivot allowing two degrees of rotational freedom is postulated in the region of the 70th base pair to account for this property of the nucleosome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Shape analysis of the histone octamer in solution.
E. Uberbacher, J. Harp, E Wilkinson-Singley, and G. Bunick (1986)
Science 232, 1247-1249
   Abstract »    PDF »
Crystals of the octameric histone core of the nucleosome.
R. Burlingame, W. Love, and E. Moudrianakis (1984)
Science 223, 413-414
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)