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Science 13 October 1978:
Vol. 202. no. 4364, pp. 225 - 227
DOI: 10.1126/science.211586
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Articles

Science, Vol 202, Issue 4364, 225-227
Copyright © 1978 by American Association for the Advancement of Science

articles

Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries

AL Betz and GW Goldstein

Capillary endothelial cells isolated from rat brain exhibit Na+-dependent uptake of the neutral amino acid analog alpha-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the antiluminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.


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Cerebral vessels have the capacity to transport sodium and potassium.
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