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Science 6 October 1978:
Vol. 202. no. 4363, pp. 70 - 71
DOI: 10.1126/science.211584
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Articles

Science, Vol 202, Issue 4363, 70-71
Copyright © 1978 by American Association for the Advancement of Science

articles

Vitamin D3-induced calcium binding protein in bone tissue

S Christakos and AW Norman

As detected by radioimmunoassay with antiserums against chick intestinal calcium binding protein (CaBP), administration of vitamin D3 to rachitic chicks causes a 25- to 100-fold increase in immunoreactive CaBP in chick bone. The bone CaBP has a higher molecular weight (approximately 34,000 daltons) than intestinal CaBP (28,000 daltons), is concentrated principally in the spongiosa and cartilage plate regions of tibia, and responds adaptively to reflect the level of dietary calcium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vitamin D deficiency inhibits pancreatic secretion of insulin.
A. Norman, J. Frankel, A. Heldt, and G. Grodsky (1980)
Science 209, 823-825
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Science. ISSN 0036-8075 (print), 1095-9203 (online)