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Science 6 October 1978:
Vol. 202. no. 4363, pp. 53 - 56
DOI: 10.1126/science.567843
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Articles

Science, Vol 202, Issue 4363, 53-56
Copyright © 1978 by American Association for the Advancement of Science

articles

Genetically determined sex-reversal in 46,XY humans

J German, JL Simpson, RS Chaganti, RL Summitt, LB Reid, and IR Merkatz

Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Report of Fertility in a Woman with a Predominantly 46,XY Karyotype in a Family with Multiple Disorders of Sexual Development.
M. Dumic, K. Lin-Su, N. I. Leibel, S. Ciglar, G. Vinci, R. Lasan, S. Nimkarn, J. D. Wilson, K. McElreavey, and M. I. New (2008)
J. Clin. Endocrinol. Metab. 93, 182-189
   Abstract »    Full Text »    PDF »
A Novel Human Sex-Determining Gene Linked to Xp11.21-11.23.
S. Rajender, K. Thangaraj, N. J. Gupta, N. Leelavathy, D. S. Rani, R. G. Nambiar, V. Kalavathy, S. T. Santhiya, S. Rajangam, P. M. Gopinath, et al. (2006)
J. Clin. Endocrinol. Metab. 91, 4028-4036
   Abstract »    Full Text »    PDF »
Genetic Approaches to Unraveling Reproductive Disorders: Examples of Bedside to Bench Research in the Genomic Era.
S. B. Seminara and W. F. Crowley Jr. (2002)
Endocr. Rev. 23, 382-392
   Abstract »    Full Text »    PDF »
Familial Sex Reversal: A Review.
K. Sarafoglou and H. Ostrer (2000)
J. Clin. Endocrinol. Metab. 85, 483-493
   Full Text »
The Y Chromosome and Primary Sexual Differentiation.
R. Bernstein (1981)
JAMA 245, 1953-1956
   Abstract »    PDF »
Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries.
R Bernstein, G. Koo, and S. Wachtel (1980)
Science 207, 768-769
   Abstract »    PDF »
The Paradox of the XY Oocyte: Relationship to Risk of Gonadoblastoma in Infant Girls.
L. I. GARDNER (1979)
Arch Pediatr Adolesc Med 133, 365-366
   Abstract »    PDF »


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