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Science 29 September 1978:
Vol. 201. no. 4362, pp. 1246 - 1249
DOI: 10.1126/science.211583
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Articles

Science, Vol 201, Issue 4362, 1246-1249
Copyright © 1978 by American Association for the Advancement of Science

articles

Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus)

WT London, SA Houff, DL Madden, DA Fuccillo, M Gravell, WC Wallen, AE Palmer, JL Sever, BL Padgett, DL Walker, GM ZuRhein, and T Ohashi

Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Squirrel Monkeys Support Replication of BK Virus More Efficiently than Simian Virus 40: an Animal Model for Human BK Virus Infection.
C. Zaragoza, R.-m. Li, G. A. Fahle, S. H. Fischer, M. Raffeld, A. M. Lewis Jr., and J. B. Kopp (2005)
J. Virol. 79, 1320-1326
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Detection of JC Polyomavirus DNA Sequences and Cellular Localization of T-Antigen and Agnoprotein in Oligodendrogliomas.
L. Del Valle, S. Enam, C. Lara, C. Ortiz-Hidalgo, C. D. Katsetos, and K. Khalili (2002)
Clin. Cancer Res. 8, 3332-3340
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Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.
J. Y.H. Kim, I. J. Koralnik, M. LeFave, R. A. Segal, L.-A. Pfister, and S. L. Pomeroy (2002)
Neuro-oncol 4, 165-170
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Expression of JC virus T-antigen in a patient with MS and glioblastoma multiforme.
L. Del Valle, S. Delbue, J. Gordon, S. Enam, S. Croul, P. Ferrante, and K. Khalili (2002)
Neurology 58, 895-900
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Polyomavirus and Medulloblastoma: A Smoking Gun or Guilt By Association?.
H. A. Fine (2002)
J Natl Cancer Inst 94, 240-241
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Expression of Human Neurotropic Polyomavirus JCV Late Gene Product Agnoprotein in Human Medulloblastoma.
L. Del Valle, J. Gordon, S. Enam, S. Delbue, S. Croul, S. Abraham, S. Radhakrishnan, M. Assimakopoulou, C. D. Katsetos, and K. Khalili (2002)
J Natl Cancer Inst 94, 267-273
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Detection of JC Virus DNA Sequences and Expression of the Viral Regulatory Protein T-Antigen in Tumors of the Central Nervous System.
L. D. Valle, J. Gordon, M. Assimakopoulou, S. Enam, J. F. Geddes, J. N. Varakis, C. D. Katsetos, S. Croul, and K. Khalili (2001)
Cancer Res. 61, 4287-4293
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Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas.
B. Krynska, L. Del Valle, S. Croul, J. Gordon, C. D. Katsetos, M. Carbone, A. Giordano, and K. Khalili (1999)
PNAS 96, 11519-11524
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JC virus DNA is present in the mucosa of the human colon and in colorectal cancers.
L. Laghi, A. E. Randolph, D. P. Chauhan, G. Marra, E. O. Major, J. V. Neel, and C. R. Boland (1999)
PNAS 96, 7484-7489
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Retinal tumor induced in the baboon by human adenovirus 12.
N Mukai, S. Kalter, L. Cummins, V. Matthews, T Nishida, and T Nakajima (1980)
Science 210, 1023-1025
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Human Polyomavirus Infections with JC Virus and BK Virus in Renal Transplant Patients.
T. F. HOGAN, E. C. BORDEN, J. A. McBAIN, B. L. PADGETT, and D. L. WALKER (1980)
Ann Intern Med 92, 373-378
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