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Science 29 September 1978:
Vol. 201. no. 4362, pp. 1234 - 1235
DOI: 10.1126/science.151328
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Articles

Science, Vol 201, Issue 4362, 1234-1235
Copyright © 1978 by American Association for the Advancement of Science

articles

Increasing adipocyte number as the basis for perirenal depot growth in adult rats

HA Bertrand, EJ Masoro, and BP Yu

The mass of the perirenal adipose depot in male Fischer 344 rats increases between 6 and 18 months of age. This increase is due to an increase in the number of adipocytes in this depot, in contrast with the concept that adipocyte number is constant throughout adult life. The epididymal depot increases in mass between 6 and 18 months of age by adipocyte hypertrophy alone.


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Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
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Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
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Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging.
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Altered expression of C/EBP family members results in decreased adipogenesis with aging.
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Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.
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