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Science 22 September 1978:
Vol. 201. no. 4361, pp. 1143 - 1145
DOI: 10.1126/science.684435
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Articles

Science, Vol 201, Issue 4361, 1143-1145
Copyright © 1978 by American Association for the Advancement of Science

articles

Secretion in mast cells induced by calcium entrapped within phospholipid vesicles

TC Theoharides and WW Douglas

Purified mast cells secreted histamine when fused to phospholipid vesicles containing calcium but not magnesium or potassium. Microscopic observation revealed highly localized exocytotic responses involving punctate extrusion of individual granules. Calcium delivered from the vesicles to the cytoplasm is apparently a sufficient stimulus to initiate exocytosis. The results support the calcium hypothesis of stimulus-secretion coupling.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells.
K. Kandere-Grzybowska, R. Letourneau, D. Kempuraj, J. Donelan, S. Poplawski, W. Boucher, A. Athanassiou, and T. C. Theoharides (2003)
J. Immunol. 171, 4830-4836
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Science. ISSN 0036-8075 (print), 1095-9203 (online)