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Science 22 September 1978:
Vol. 201. no. 4361, pp. 1094 - 1101
DOI: 10.1126/science.356268
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Articles

Science, Vol 201, Issue 4361, 1094-1101
Copyright © 1978 by American Association for the Advancement of Science

articles

Research involving human subjects

BH Gray, RA Cooke, and AS Tannenbaum

This article reports a study of the activities and performance of institutional review boards to protect human research subjects. Researchers and institutional review board members were generally supportive of the review system, although substantial criticisms were also heard. Institutional review boards had some direct impact on half of the proposals reviewed by requiring either modification of or additional information about proposed research. The data, however, raise questions about the effectiveness of some review board actions, for example, with regard to informed consent. Some policy implications of the study are presented.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)