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Science 15 September 1978:
Vol. 201. no. 4360, pp. 1023 - 1025
DOI: 10.1126/science.567376
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Articles

Science, Vol 201, Issue 4360, 1023-1025
Copyright © 1978 by American Association for the Advancement of Science

articles

Phagocytosis in the retinal pigment epithelium of the RCS rat

AI Goldman and PJ O'Brien

The retinal pigment epithelium of RCS rats, previously thought not to phagocytize photoreceptor outer segments, exhibited a peak of phagocytosis in vivo when animals were kept under conditions of cyclic lighting (12 hours of darkness and 12 hours of light). The peak occurred at 1 hour after the onset of light, with maximum and minimum levels of phagocytosis averaging about 5 percent of that found in the pigment epithelium of Osborn-Mendel rats used as a control. Eyecups that were obtained from Osborn-Mendel rats and maintained for up to 3 hours in organ culture demonstrated levels of phagocytosis that were sevenfold greater than those of unincubated controls. Likewise a tenfold increase occurred in incubated as opposed to unicubated RCS eyes, raising the possibility that phagocytosis could be experimentally stimulated in vivo.


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