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Science 8 September 1978:
Vol. 201. no. 4359, pp. 916 - 918
DOI: 10.1126/science.356265
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Articles

Science, Vol 201, Issue 4359, 916-918
Copyright © 1978 by American Association for the Advancement of Science

articles

Unusual antibody-induced modulation of surface antigens in the cell coat of a bloodstream trypanosome

MS Giannini and PA D'Alesandro

Unlike other eukaryotic cells, Trypanosoma lewisi forms caps at 0 degrees C when incubated with rabbit immunoglobulin G(IgG) directed against surface IgG from the rat host. The host IgG, which is specific for parasite antigens, probably does not cause capping of these antigens in vivo, since trypanosomes treated with Fab fragments directed against rat IgG are uniformly labeled and do not cap at 0 degrees C or 37 degrees C.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)