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Science 8 September 1978:
Vol. 201. no. 4359, pp. 875 - 880
DOI: 10.1126/science.210504

Articles

Science, Vol 201, Issue 4359, 875-880
Copyright © 1978 by American Association for the Advancement of Science


articles

The biology of oxygen radicals

I Fridovich

The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen. An unusual family of enzymes, the superoxide dismutases, protect against the deleterious actions of this radical by catalyzing its dismutation to hydrogen peroxide plus oxygen.


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M. O. Clements, S. P. Watson, and S. J. Foster (1999)
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Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall.
J. W. HEINECKE (1999)
FASEB J 13, 1113-1120
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Regulation of lung manganese superoxide dismutase: species variation in response to lipopolysaccharide.
G. Dirami, D. Massaro, and L. B. Clerch (1999)
Am J Physiol Lung Cell Mol Physiol 276, L705-L708
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The bspA Locus of Lactobacillus fermentum BR11 Encodes an L-Cystine Uptake System.
M. S. Turner, T. Woodberry, L. M. Hafner, and P. M. Giffard (1999)
J. Bacteriol. 181, 2192-2198
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Inhibition of copper/zinc superoxide dismutase impairs NO ·-mediated endothelium-dependent relaxations.
C. O. Wambi-Kiesse and Z. S. Katusic (1999)
Am J Physiol Heart Circ Physiol 276, H1043-H1048
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JunB Forms the Majority of the AP-1 Complex and Is a Target for Redox Regulation by Receptor Tyrosine Kinase and G Protein-coupled Receptor Agonists in Smooth Muscle Cells.
G. N. Rao, K. A. Katki, N. R. Madamanchi, Y. Wu, and M. J. Birrer (1999)
J. Biol. Chem. 274, 6003-6010
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A New Antioxidant with Alkyl Hydroperoxide Defense Properties in Yeast.
J. Lee, D. Spector, C. Godon, J. Labarre, and M. B. Toledano (1999)
J. Biol. Chem. 274, 4537-4544
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Gene Transfer of Mitochondrially Targeted Glutathione Reductase Protects H441 Cells from t-Butyl Hydroperoxide-Induced Oxidant Stresses.
D. J. O'Donovan, J. P. Katkin, T. Tamura, R. Husser, X. Xu, C. V. Smith, and S. E. Welty (1999)
Am. J. Respir. Cell Mol. Biol. 20, 256-263
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Bicarbonate Is Required for the Peroxidase Function of Cu,Zn-Superoxide Dismutase at Physiological pH.
S. Sankarapandi and J. L. Zweier (1999)
J. Biol. Chem. 274, 1226-1232
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A Mechanism of Resistance to Hydrogen Peroxide in Vibrio rumoiensis S-1.
N. Ichise, N. Morita, T. Hoshino, K. Kawasaki, I. Yumoto, and H. Okuyama (1999)
Appl. Envir. Microbiol. 65, 73-79
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