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Science 1 September 1978:
Vol. 201. no. 4358, pp. 835 - 837
DOI: 10.1126/science.684411
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Articles

Science, Vol 201, Issue 4358, 835-837
Copyright © 1978 by American Association for the Advancement of Science

articles

Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability

HL Henry and AW Norman

When hens are raised to sexual maturity from hatching with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] as their sole source of cholecalciferol (vitamin D3), fertile eggs appear to develop normally but fail to hatch. When hens receive a combination of 1,25(OH)2D3 and 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3], hatchability equivalent to that with hens given vitamin D3 is obtained. These results suggest a biological role for 24,25(OH)2D3 not previously recognized.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats.
H. Hamamoto, T. Kusudo, N. Urushino, H. Masuno, K. Yamamoto, S. Yamada, M. Kamakura, M. Ohta, K. Inouye, and T. Sakaki (2006)
Mol. Pharmacol. 70, 120-128
   Abstract »    Full Text »    PDF »
Vitamin D deficiency, muscle function, and falls in elderly people.
H. C. Janssen, M. M Samson, and H. J. Verhaar (2002)
Am. J. Clinical Nutrition 75, 611-615
   Full Text »    PDF »
Transcriptional Regulation of the Vitamin D3 Receptor Gene by ZEB.
D. L. Lazarova, M. Bordonaro, and A. C. Sartorelli (2001)
Cell Growth Differ. 12, 319-326
   Abstract »    Full Text »    PDF »
Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D.
R. St-Arnaud, A. Arabian, R. Travers, F. Barletta, M. Raval-Pandya, K. Chapin, J. Depovere, C. Mathieu, S. Christakos, M. B. Demay, et al. (2000)
Endocrinology 141, 2658-2666
   Abstract »    Full Text »    PDF »
Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog.
K.-I. Takeyama, Y. Masuhiro, H. Fuse, H. Endoh, A. Murayama, S. Kitanaka, M. Suzawa, J. Yanagisawa, and S. Kato (1999)
Mol. Cell. Biol. 19, 1049-1055
   Abstract »    Full Text »    PDF »
Editorial: 24, 25-Dihydroxyvitamin D--Active Metabolite or Inactive Catabolite?.
R. St-Arnaud and F. H. Glorieux (1998)
Endocrinology 139, 3371-3374
   Full Text »    PDF »
24R,25-Dihydroxyvitamin D3: An Essential Vitamin D3 Metabolite for Both Normal Bone Integrity and Healing of Tibial Fracture in Chicks.
E.-G. Seo, T. A. Einhorn, and A. W. Norman (1997)
Endocrinology 138, 3864-3872
   Abstract »    Full Text »    PDF »
Mouse Vitamin D-24-Hydroxylase: Molecular Cloning, Tissue Distribution, and Transcriptional Regulation by 1{alpha},25-Dihydroxyvitamin D3.
N. Akeno, S. Saikatsu, T. Kawane, and N. Horiuchi (1997)
Endocrinology 138, 2233-2240
   Abstract »    Full Text »    PDF »
24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks?.
S Ameenuddin, M Sunde, H. DeLuca, N Ikekawa, and Y Kobayashi (1982)
Science 217, 451-452
   Abstract »    PDF »
Vitamin D deficiency inhibits pancreatic secretion of insulin.
A. Norman, J. Frankel, A. Heldt, and G. Grodsky (1980)
Science 209, 823-825
   Abstract »    PDF »


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