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Science 18 August 1978:
Vol. 201. no. 4356, pp. 649 - 651
DOI: 10.1126/science.209541
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Articles

Science, Vol 201, Issue 4356, 649-651
Copyright © 1978 by American Association for the Advancement of Science

articles

Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice

JH Thurston, RE Hauhard, and JA Dirgo

In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.


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Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)