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Science 18 August 1978:
Vol. 201. no. 4356, pp. 637 - 639
DOI: 10.1126/science.675249
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Articles

Science, Vol 201, Issue 4356, 637-639
Copyright © 1978 by American Association for the Advancement of Science

articles

Lead exposure during infancy permanently increases lithium-induced polydipsia

RB Mailman, MR Krigman, RA Mueller, P Mushak, and GR Breese

Lead (200 milligrams per kilogram) was administered daily by intubation to Long-Evans rats on days 3 through 30 of life. Thirty to 180 days after cessation of lead administration, the lead-treated rats were consistently more polydipsic after lithium administration (2 millimoles per kilogram per day) than were pair-treated controls. Lithium increased the plasma renin activity equally in both the lead treated and the control groups. These data are evidence that there may be permanent neural changes induced by postnatal exposure to lead that are manifested by pharmacological challenge with lithium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lead enhancement of lithium-induced polydipsia.
R. Wedeen (1979)
Science 205, 725-726
   PDF »
Lead Enhancement of Lithium-Induced Polydipsia.
R. B. MAILMAN, G. R. BREESE, M. R. KRIGMAN, P. MUSHAK, and R. A. MUELLER (1979)
Science 205, 726
   PDF »


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