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Science 18 August 1978:
Vol. 201. no. 4356, pp. 620 - 622
DOI: 10.1126/science.675245
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Articles

Science, Vol 201, Issue 4356, 620-622
Copyright © 1978 by American Association for the Advancement of Science

articles

Left ventricular receptors inhibit brain serotonin neurons during coronary artery occlusion

MJ Sole, G Van Loon, A Shum, W Lixfield, and DC MacGregor

Acute coronary artery ligation in pargyline-treated rats decreased serotonin and increased 5-hydroxyindoleacetic acid in the medulla and posterior hypothalamus. Lidocaine applied topically to the left ventricle completely prevented these alterations. No changes in serotonin were observed in the other brain regions examined. These data suggest a reflex inhibition of bulbar and hypothalamic serotonergic nerves by left ventricular receptors following acute coronary artery occlusion in the rat.


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