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Science 11 August 1978:
Vol. 201. no. 4355, pp. 543 - 544
DOI: 10.1126/science.663674
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Articles

Science, Vol 201, Issue 4355, 543-544
Copyright © 1978 by American Association for the Advancement of Science

articles

Disulfiram enhances pharmacological activity of barbital and impairs its urinary elimination

M Sharkawi and D Cianflone

Disulfiram or diethyldithiocarbamate significantly enhanced the sleeping time induced by barbital in rats. At identical time intervals after rats were injected with barbital the concentration of barbital in the blood or brain of animals that had previously received disulfiram was significantly higher than the concentrations in the corresponding tissues of control animals. Urinary excretion of barbital was significantly reduced in disulfiram-treated animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cutaneous Reactions to Lower Aliphatic Alcohols Before and During Disulfiram Therapy.
N. F. Haddock and J. K. Wilkin (1982)
Arch Dermatol 118, 157-159
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Science. ISSN 0036-8075 (print), 1095-9203 (online)