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Science 11 August 1978:
Vol. 201. no. 4355, pp. 538 - 541
DOI: 10.1126/science.96532
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Articles

Science, Vol 201, Issue 4355, 538-541
Copyright © 1978 by American Association for the Advancement of Science

articles

Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis

NJ Alexander and TB Clarkson

Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (Macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. The effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
RE: "INVITED COMMENTARY: HORMONE THERAPY AND RISK OF CORONARY HEART DISEASE WHY RENEW THE FOCUS ON THE EARLY YEARS OF MENOPAUSE?".
L. Rosenberg (2007)
Am. J. Epidemiol. 166, 1480-1481
   Full Text »    PDF »
High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis.
D J Grainger and H W L Bethell (2002)
Ann Rheum Dis 61, 110-114
   Abstract »    Full Text »    PDF »
Vasectomy and Health: Results From a Large Cohort Study.
F. J. Massey Jr, G. S. Bernstein, W. M. O'Fallon, L. M. Schuman, A. H. Coulson, R. Crozier, J. S. Mandel, R. B. Benjamin, H. W. Berendes, P. C. Chang, et al. (1984)
JAMA 252, 1023-1029
   Abstract »    PDF »
Immunologic Aspects of Heart Disease.
S. DeCarvalho (1982)
Angiology 33, 427-441
   Abstract »    PDF »
Hospitalization Rates in Vasectomized Men.
A. M. Walker, H. Jick, J. R. Hunter, A. Danford, and K. J. Rothman (1981)
JAMA 245, 2315-2317
   Abstract »    PDF »


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