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Science 11 August 1978:
Vol. 201. no. 4355, pp. 527 - 529
DOI: 10.1126/science.248241
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Articles

Science, Vol 201, Issue 4355, 527-529
Copyright © 1978 by American Association for the Advancement of Science

articles

Histidine transfer RNA levels in Friend leukemia cells: stimulation by histidine deprivation

M Litt and K Weiser

Friend leukemia cells incubated with sublethal concentrations of histidinol for 5 to 6 days show up to twofold increases in their relative concentrations of histidine transfer RNA and no change in the relative concentrations of leucine transfer RNA. A similar effect is seen when cells are grown to stationary phase in the presence of 0.2 times the amount of histidine in Eagle's minimum essential medium. These observations support the theory that the concentrations of specific transfer RNA's are regulated by a mechanism that is sensitive to the extent of their aminoacylation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)