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Science 4 August 1978:
Vol. 201. no. 4354, pp. 457 - 459
DOI: 10.1126/science.663667
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Articles

Science, Vol 201, Issue 4354, 457-459
Copyright © 1978 by American Association for the Advancement of Science

articles

Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks

PJ Fischinger, CS Blevins, and NM Dunlop

HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mobilization of Endogenous Retroviruses in Mice after Infection with an Exogenous Retrovirus.
L. H. Evans, A. S. M. Alamgir, N. Owens, N. Weber, K. Virtaneva, K. Barbian, A. Babar, F. Malik, and K. Rosenke (2009)
J. Virol. 83, 2429-2435
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Science. ISSN 0036-8075 (print), 1095-9203 (online)