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Science 4 August 1978:
Vol. 201. no. 4354, pp. 406 - 415
DOI: 10.1126/science.208155
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Articles

Science, Vol 201, Issue 4354, 406-415
Copyright © 1978 by American Association for the Advancement of Science

articles

Higher order structure of simian virus 40 chromatin

U Muller, H Zentgraf, I Eicken, and W Keller

Simian virus 40 nucleoprotein complexes undergo an ionic strength-dependent structural transition. At moderate ionic strength they contain histone H1 as well as the nucleosomal histones and have a compact conformation with globular subunits 190 angstroms in diameter. At high ionic strength histone H1 is released, and the structure unfolds into chains with an average of 24 nucleosomes. The extended viral chromatin converts to the compact form by the addition of histone H1. Transcriptionally active simian virus 40 chromatin undergoes the same structural transitions. The higher order structure of viral chromatin may be analogous to the compact state of cellular chromatin fibers observed at physiological ionic strength.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Minor Capsid Proteins of Simian Virus 40 Are Dispensable for Nucleocapsid Assembly and Cell Entry but Are Required for Nuclear Entry of the Viral Genome.
A. Nakanishi, N. Itoh, P. P. Li, H. Handa, R. C. Liddington, and H. Kasamatsu (2007)
J. Virol. 81, 3778-3785
   Abstract »    Full Text »    PDF »
JC Virus Minor Capsid Proteins Vp2 and Vp3 Are Essential for Virus Propagation..
M. L. Gasparovic, G. V. Gee, and W. J. Atwood (2006)
J. Virol. 80, 10858-10861
   Abstract »    Full Text »    PDF »
Stimulation of DNA Replication from the Polyomavirus Origin by PCAF and GCN5 Acetyltransferases: Acetylation of Large T Antigen.
A.-Y. Xie, V. P. Bermudez, and W. R. Folk (2002)
Mol. Cell. Biol. 22, 7907-7918
   Abstract »    Full Text »    PDF »
Reactivation of the Human Cytomegalovirus Major Immediate-Early Regulatory Region and Viral Replication in Embryonal NTera2 Cells: Role of Trichostatin A, Retinoic Acid, and Deletion of the 21-Base-Pair Repeats and Modulator.
J. L. Meier (2001)
J. Virol. 75, 1581-1593
   Abstract »    Full Text »
A nucleoprotein complex mediates the integration of retroviral DNA..
B Bowerman, P O Brown, J M Bishop, and H E Varmus (1989)
Genes & Dev. 3, 469-478
   Abstract »    PDF »
Simian virus 40 crystals.
E. Lattman (1980)
Science 208, 1048-1050
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)