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Science 28 July 1978:
Vol. 201. no. 4353, pp. 373 - 376
DOI: 10.1126/science.566471
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Articles

Science, Vol 201, Issue 4353, 373-376
Copyright © 1978 by American Association for the Advancement of Science

articles

Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance

SH Ackerman, MA Hofer, and H Weiner

Rat pups that are separated early from their mothers, at postnatal day 15, become hypothermic when subjected to physical restraint on postnatal day 30. Restraint of separated pups also elicits an unusually high incidence of gastric erosions, as well as insomnia and an increase in quiet wakefulness. If hypothermia during restraint is prevented, neither the erosions nor the behavioral responses occur. Rat pups separated at the customary age (postnatal day 22) do not become hypothermic during restraint, and the restraint of such pups is not associated with either gastric erosion or insomnia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Am J Physiol Regulatory Integrative Comp Physiol 292, R308-R315
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Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats.
F Barreau, L Ferrier, J Fioramonti, and L Bueno (2004)
Gut 53, 501-506
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