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Science 28 July 1978:
Vol. 201. no. 4353, pp. 367 - 369
DOI: 10.1126/science.208153
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Articles

Science, Vol 201, Issue 4353, 367-369
Copyright © 1978 by American Association for the Advancement of Science

articles

Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism

PE Gold and DB Sternberg

This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor.
C. E. Canal, Q. Chang, and P. E. Gold (2007)
PNAS 104, 12500-12505
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The many faces of amnesia..
P. E. Gold (2006)
Learn. Mem. 13, 506-514
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Phase shifting circadian rhythms produces retrograde amnesia.
W. Tapp and F. Holloway (1981)
Science 211, 1056-1058
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Neurobiology of amnesia.
L. Squire, H. Davis, and C. Spanis (1980)
Science 209, 836-837
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