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Science 28 July 1978:
Vol. 201. no. 4353, pp. 352 - 355
DOI: 10.1126/science.26976
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Articles

Science, Vol 201, Issue 4353, 352-355
Copyright © 1978 by American Association for the Advancement of Science

articles

Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea

ST Mason, PR Sanberg, and HC Fibiger

Kainic acid lesion of cell bodies in the dorsal striatum enhanced the stereotypy-producing effects of d-amphetamine without affecting the sterotypy produced by the direct receptor agonist apomorphine. This pattern of results parallels that found in patients suffering from Hungtington's chorea, thus strengthening the parallels between the kainic acid animal model and the human disease state initially suggested on biochemical gounds. The present results further suggest a dissociation of the mechanisms involved in the production of stereotypy by these two drugs, perhaps in terms of differential involvement of the striato-nigral negative feedback loop.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
On the specificity of kainic acid.
S. Mason and H. Fibiger (1979)
Science 204, 1339-1341
   Abstract »    PDF »
Sedative Effects of Apomorphine in an Animal Model of Huntington's Disease.
P. R. Sanberg, J. Lehmann, and H. C. Fibiger (1979)
Arch Neurol 36, 349-350
   Abstract »    PDF »


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