Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 July 1978:
Vol. 201. no. 4352, pp. 274 - 276
DOI: 10.1126/science.351808
Prev | Table of Contents | Next

Articles

Science, Vol 201, Issue 4352, 274-276
Copyright © 1978 by American Association for the Advancement of Science

articles

Human serial learning: enhancement with arecholine and choline impairment with scopolamine

N Sitaram, H Weingartner, and JC Gillin

Arecholine (4 milligrams), a cholinergic agonist, and choline (10 grams), a precursor of acetylcholine, significantly enhanced serial learning in normal human subjects. The subjects received methscopolamine prior to both arecholine and placebo injections. Conversely, scopolamine (0.5 milligram), a cholinergic antagonist, impaired learning and this impairment was reversed by arecholine and choline and the impairment after scopolamine were inversely proportional to the subject's performance on placebo; that is, "poor" performers were more vulnerable to both the enhancing effect of cholinergic agonist and precursor and the impairment after cholinergic antagonist than "good" performers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia.
J. A. Gray and B. L. Roth (2007)
Schizophr Bull 33, 1100-1119
   Abstract »    Full Text »    PDF »
Donepezil Effects on Cerebral Blood Flow in Older Adults With Mild Cognitive Deficits.
X. Chen, V. A. Magnotta, K. Duff, L. L. Boles Ponto, and S. K. Schultz (2006)
J Neuropsychiatry Clin Neurosci 18, 178-185
   Abstract »    Full Text »    PDF »
Neuropsychological Test Performance in Healthy Volunteers Before and After Donepezil Administration.
L. J. Beglinger, B. L. Gaydos, D. A. Kareken, O. Tangphao-Daniels, E. R. Siemers, and R. C. Mohs (2004)
J Psychopharmacol 18, 102-108
   Abstract »    PDF »
From The Cover: Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation.
S. Gais and J. Born (2004)
PNAS 101, 2140-2144
   Abstract »    Full Text »    PDF »
Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease.
P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan (2003)
J. Biol. Chem. 278, 26888-26896
   Abstract »    Full Text »    PDF »
Activation of Muscarinic Receptors Inhibits beta -Amyloid Peptide-induced Signaling in Cortical Slices.
Z. Gu, P. Zhong, and Z. Yan (2003)
J. Biol. Chem. 278, 17546-17556
   Abstract »    Full Text »    PDF »
Muscarinic Potentiation of GABAA Receptor Currents Is Gated by Insulin Signaling in the Prefrontal Cortex.
X.-H. Ma, P. Zhong, Z. Gu, J. Feng, and Z. Yan (2003)
J. Neurosci. 23, 1159-1168
   Abstract »    Full Text »    PDF »
Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia.
K. L. Lanctôt, N. Herrmann, and P. Mazzotta (2001)
J Neuropsychiatry Clin Neurosci 13, 5-21
   Abstract »    Full Text »
Verbal and Visual Memory Improve After Choline Supplementation in Long-Term Total Parenteral Nutrition: A Pilot Study.
A. L. Buchman, M. Sohel, M. Brown, D. J. Jenden, C. Ahn, M. Roch, and T. L. Brawley (2001)
JPEN J Parenter Enteral Nutr 25, 30-35
   Abstract »    PDF »
.
H. Tsukada, T. Kakiuchi, I. Ando, and Y. Ouchi (1997)
J. Pharmacol. Exp. Ther. 281, 1408-1414
   Abstract »
Citicoline Improves Verbal Memory in Aging.
P. A. Spiers, D. Myers, G. S. Hochanadel, H. R. Lieberman, and R. J. Wurtman (1996)
Arch Neurol 53, 441-448
   Abstract »    PDF »
The effects of thyrotropin-releasing hormone and scopolamine in Alzheimer's disease and normal volunteers.
S. E. Molchan, A. M. Mellow, J. L. Hill, H. Weingartner, R. Martinez, B. Vitiello, and T. Sunderland (1992)
J Psychopharmacol 6, 489-500
   Abstract »    PDF »
A New Assessment Tool for Neuropsychopharmacologic Research: The Computerized Neuropsychological Test Battery.
A. E. Veroff, N. R. Cutler, J. J. Sramek, P. L. Prior, W. Mickelson, and J. K. Hartman (1991)
J Geriatr Psychiatry Neurol 4, 211-217
   Abstract »    PDF »
The use of a scopolamine model to study the potential nootropic effects of aniracetam and piracetam in healthy volunteers.
K. Wesnes, R. Anand, P. Simpson, and L. Christmas (1990)
J Psychopharmacol 4, 219-232
   Abstract »    PDF »
Snipping the Thread of Life: Antimuscarinic Side Effects of Medications in the Elderly.
N. L. Peters (1989)
Arch Intern Med 149, 2414-2420
   Abstract »    PDF »
Multiple-Dose Arecoline Infusions in Alzheimer's Disease.
P. N. Tariot, R. M. Cohen, J. A. Welkowitz, T. Sunderland, P. A. Newhouse, D. L. Murphy, and H. Weingartner (1988)
Arch Gen Psychiatry 45, 901-905
   Abstract »    PDF »
The Effects of Acute Scopolamine in Geriatric Depression.
P. A. Newhouse, T. Sunderland, P. N. Tariot, H. Weingartner, K. Thompson, A. M. Mellow, R. M. Cohen, and D. L. Murphy (1988)
Arch Gen Psychiatry 45, 906-912
   Abstract »    PDF »
Anticholinergic Sensitivity in Patients With Dementia of the Alzheimer Type and Age-Matched Controls: A Dose-Response Study.
T. Sunderland, P. N. Tariot, R. M. Cohen, H. Weingartner, E. A. Mueller III, and D. L. Murphy (1987)
Arch Gen Psychiatry 44, 418-426
   Abstract »    PDF »
Attention Dysfunction and Psychopathology in College Men.
M. S. Buchsbaum, R. J. Haier, A. J. Sostek, H. Weingartner, T. P. Zahn, L. J. Siever, D. L. Murphy, and L. Brody (1985)
Arch Gen Psychiatry 42, 354-360
   Abstract »    PDF »
A Family With Histologically Confirmed Alzheimer's Disease.
L. E. Nee, R. J. Polinsky, R. Eldridge, H. Weingartner, S. Smallberg, and M. Ebert (1983)
Arch Neurol 40, 203-208
   Abstract »    PDF »
Alzheimer's disease: a disorder of cortical cholinergic innervation.
J. Coyle, D. Price, and M. DeLong (1983)
Science 219, 1184-1190
   Abstract »    PDF »
Effects of Anticholinergic Drugs on Memory in Parkinson's Disease.
M. Sadeh, J. Braham, and M. Modan (1982)
Arch Neurol 39, 666-667
   Abstract »    PDF »
The cholinergic hypothesis of geriatric memory dysfunction.
R. Bartus, R. Dean 3rd, B Beer, and A. Lippa (1982)
Science 217, 408-414
   Abstract »    PDF »
Neural Bases of Intelligence and Training.
M. R. Rosenzweig (1981)
Journal of Special Education 15, 105-123
   Abstract »    PDF »
Effects of vasopressin on human memory functions.
H Weingartner, P Gold, J. Ballenger, S. Smallberg, R Summers, D. Rubinow, R. Post, and F. Goodwin (1981)
Science 211, 601-603
   Abstract »    PDF »
Cognitive Processes in Depression.
H. Weingartner, R. M. Cohen, D. L. Murphy, J. Martello, and C. Gerdt (1981)
Arch Gen Psychiatry 38, 42-47
   Abstract »    PDF »
Memory and Cognitive Function in the Elderly: A Preliminary Trial of Physostigmine.
D. A. Drachman and B. J. Sahakian (1980)
Arch Neurol 37, 674-675
   Abstract »    PDF »
Mood and behavioral effects of physostigmine on humans are accompanied by elevations in plasma beta-endorphin and cortisol.
S. Risch, R. Cohen, D. Janowsky, N. Kalin, and D. Murphy (1980)
Science 209, 1545-1546
   Abstract »    PDF »
Long-term choline treatment of memory-impaired elderly patients.
S. Ferris, G Sathananthan, B Reisberg, and S Gershon (1979)
Science 205, 1039-1040
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)